Here Are A Few Research Studies That Discuss The Use Of DHT For Penile Growth:
Kinetics and Effect of Percutaneous Administration of Dihydrotestosterone in Children
Evangelia Charmandaria, Mehul T. Dattania, Leslie A. Perryb, Peter C. Hindmarsha, Charles G.D. Brooka
BACKGROUND: Percutaneous administration of dihydrotestosterone (DHT) has been successful in promoting phallic growth in infants and children with 5 alpha-reductase deficiency raised as males. We investigated whether percutaneous administration of DHT is similarly effective in patients with micropenis due to alternative diagnoses.
METHODS: Six patients (age range 1.9-8.3 years) with micropenis of variable etiology were studied prospectively. 2.5% DHT gel was applied to the phallus once daily at a dose of 0.15-0.33 mg/kg body weight. Serum DHT concentrations were measured at 0, 2, 4, 8, 12 and 24 h following application of DHT gel.
RESULTS: Peak DHT concentrations were attained within 2-8 h after application of the gel and subsequently remained within the normal adult range in all but 1 patient, who had received the lowest dose of 0.15 mg/kg. An increase in phallic growth, ranging from 0.5-2.0 cm, was achieved after 3-4 months of treatment in all patients whose DHT concentrations were maintained within adult range.
CONCLUSION: Percutaneous administration of DHT in a dose of 0.2-0.3 mg/kg once daily for a period of 3-4 months may be useful in the management of patients with testosterone biosynthetic defects, who have sufficient masculinization to warrant male sex assignment, or in patients with micropenis prior to reconstructive surgery.
Copyright 2002 S. Karger AG, Basel
Micropenis and the 5-Reductase-2
(SRD5A2) Gene: Mutation and V89L Polymorphism Analysis in 81 Japanese Patients
Goro Sasaki, Tsutomu Ogata, Tomohiro Ishii, Kenjiro Kosaki, Seiji Sato, Keiko Homma, Takao Takahashi, Tomonobu Hasegawa and Nobutake Matsuo
Department of Pediatrics, Keio University School of Medicine (G.S., T.I., K.K., T.T., T.H.), Tokyo 160-8582; National Research Institute for Child Health and Development (T.O.), Tokyo 154-8567; Department of Pediatrics, Saitama Municipal Hospital (S.S.), Saitama 336-8522; Department of Laboratory Medicine, Keio University School of Medicine (K.H.), Tokyo 160-8582; and National Center for Child Health and Development (N.M.), Tokyo 157-8535, Japan
Clinical findings of cases 1–3 are summarized in Table 2. Cases 1 and 2 had micropenis below -2.5 SD, and case 3 had mild micropenis of -2.4 SD together with bilateral undescended testes at the position of the external inguinal rings. The testes of case 3 could be manipulated to the upper scrotal regions but immediately ascended to their original positions. Human chorionic gonadotropin (hCG) tests (3000 IU/m2 per dose im for 3 consecutive days; blood sampling on d 1 and 4) showed markedly elevated T/5DHT ratios, together with poor T response in case 3. GnRH tests (100 µg/m2 bolus iv; blood sampling at 0, 30, 60, 90, and 120 min) resulted in normal FSH and LH responses, except for a mild FSH hyperresponse in case 3. Analyses of steroid hormone metabolites for random urine samples by a gas chromatograph-mass spectrometry revealed markedly increased ratios of 5ß to 5 metabolites, especially for tetrahydrocortisol (THF) derived from cortisol. Because cases 1–3 and/or their parents hoped to receive therapy immediately, 25 mg of testosterone enanthate (TE) was administrated im two or three times with an interval of more than 4 wk, resulting in subnormal penile length responses. After establishing the diagnosis of 5-reductase-2 deficiency, 12.5 or 25 mg of 5DHT (Andractim gel, Laboratories Besins Iscovesco, Paris, France) was transdermally applied to the genital region once per day for 8 or 16 wk according to the method of Choi et al. (23), increasing the penile length to nearly the average of age-matched Japanese boys.
The Child With Micropenis.
Indian J Pediatr. 2000 Jun;67(6):455-60.
Menon PS, Khatwa UA.
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.
Micropenis refers to an extremely small penis with a stretched penile length of less than 2.5 SD below the mean for age or stage of sexual development. It should be differentiated from a buried or hidden penis and aphallia. It is important to use a standard technique of stretched penile measurement and nomograms for age to identify children with micropenis. All children above 1 year of age with a stretched penile length of less than 1.9 cm need evaluation. Based on etiology they can be classified as hypogonadotropic hypogonadism (hypothalamic or pituitary failure), hypergonadotropic hypogonadism (testicular failure), partial androgen insensitivity syndrome and idiopathic groups. The help of a pediatric endocrinologist, geneticist, pediatric surgeon and/or urologist is often necessary. Growth velocity is an important determinant of associated hypothalamic or pituitary pathology. GnRH and/or hCG stimulation tests are often helpful in evaluating the etiology. Similarly chromosomal studies are indicated in a few. Often the diagnosis is inferred by the presence of clinical features suggestive of a syndrome usually associated with hypogonadotropic hypogonadism. Irrespective of the underlying cause a short course of testosterone should be tried in patients with micropenis and an assessment of the penis to respond should be made. Transdermal DHT has also been reported to be effective in prepubertal children. Children with hypopituitarism and GH deficiency respond to appropriate hormonal therapy. Surgical correction is not indicated in the common endocrine types of micropenis. Many studies have shown that most testosterone treated children have satisfactory gain in length of penis and sexual function. Thus sexual reassignment is done very infrequently now.
PMID: 10932967 [PubMed - indexed for MEDLINE]
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